Diablo 4 Unlock All Vampiric Powers
Image: Blizzard Entertainment

How to get all 22 Vampiric Powers in Diablo 4, explained

Get read to bleed Diablo 4 dry.

It’s only natural to want to unlock all 22 Vampiric Powers in Diablo 4. Some are just okay, but others are extremely powerful. In this guide, I’ll teach you the three ways you can unlock all 22 Vampiric Powers in Diablo 4.

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All ways to unlock Vampiric Powers in Diablo 4

There are three ways to unlock Vampiric Powers in Diablo 4. Here are those three ways:

  • Use Potent Blood
  • Complete seasonal Campaign Quests
  • Earn Hunters Acclaim
Diablo 4 Vampiric Powers Unlock
Image: Blizzard Entertainment

The best way to unlock all Vampiric Powers in Diablo 4 is by completing Blood Harvests. Blood Harvests are very similar to Helltides. A large section of the map is turned into a Blood Harvest zone. Within it, you’ll encounter Pact armor, Seeker Caches, and Blood Seekers. Most importantly for unlocking Vampiric Powers, you’ll get Hunters Acclaim and Potent Blood.

In Blood Harvests, you hit two birds with one stone by earning more Hunters Acclaim and by collecting Potent Blood. Hunters Acclaim is a reputation mechanic that is quickly earned when completing activities in a Blood Harvest. As you defeat monsters and Blood Seekers and open Seeker Caches all within a Blood Harvest, you earn Potent Blood which is the required currency to unlock and upgrade Vampiric Powers.

In general, the fastest way to unlock Vampiric Powers is through Potent Blood. When you spend Potent Blood, it unlocks a random Vampiric Power. You can do this 22 times to get all the Vampiric Powers. I don’t recommend getting them all. You’ll want to save some Potent Blood to upgrade your favorite Vampiric Powers.

However, you can also earn Vampiric Powers by earning Hunters Acclaim and by completing the Campaign Quests attached to Season of Blood. I recommend doing both of these activities as it’ll save you from constantly spending Potent Blood by giving you several Vampiric Powers while you hunt for Potent Blood.

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Noah Nelson
From his early days of blog-style music, movie, and game reviews to working as the Esports Writer at Coastline Community College, Noah Nelson now works fulltime as a Staff Writer for Attack of the Fanboy and PC Invasion. He has been helping gamers everywhere with Destiny 2 god rolls, Warzone 2 DMZ missions, and collectibles in any indie game for over a year and a half. His Bachelor's Degree in English Rhetoric and Composition with a minor in Journalism from CSULB has shaped him to be a strong writer and editor. His fondest gaming memory is playing Sly Cooper 2 after begging his mom (for hours) to play it before his birthday and he still cries myself to sleep remembering the time he accidentally saved over his 99% completion save file in Kingdom Hearts 2.